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Belgian doctors helped 40 volunteers get rid of type 2 diabetes, reduce cholesterol and improve liver function, using Akkermansia bacteria cultures.
Nature Medicine published their findings.
"In addition to the improvements in metabolism, our volunteers also shed about 2 extra kg and 2.5 cm of hips, while at the same time, we must understand that our experiments are only the first successful step in establishing Means that will solve all these problems in clinical cases. "
The human body contains about ten times more monoclonal bacteria, fungi and other species than its body cells. Recent years' observations show that human bacteria can not only affect the metabolism and the risk of cancer and other diseases, but also human behavior.
For example, a year ago, American biologists, who conducted experiments on mice, discovered that the development of autism may be due to the absence of Lactobasillus reuteri bacteria in the intestines of children and their mothers.
Ten years ago, Kani and his colleagues discovered one of the first patterns of this type and experimented with mice. Scientists have observed that in the intestines of healthy and obese people, Akkermansia bacteria are much more abundant than those found in the digestive tract of diabetic patients and obese men and women.
Guided by this idea, biologists have verified what will happen if we start feeding rodents in large amounts of these microbes. This experiment ended well: mice not only got rid of obesity and diabetes, but also from many other problems due to metabolic failure.
Moreover, two years ago, scientists discovered that a greater effect could be achieved if one did not use "live" microbes, but vaporized it by placing the bacteria in a "warm bath" for half an hour. The rats that feed on Akkermansia's "soup" lived longer because of lower cholesterol levels.
The transmission of the results of these experiments to humans was complicated because, until recently, scientists could not cultivate these bacteria outside the rodents' digestive system, making them impossible to use in clinical trials. More recently, Kani and his team have solved this problem by creating an artificial environment in which Akkermansia can grow.
After this success, scientists gathered a group of forty obese and type 2 diabetes patients and invited them to take tablets every day containing live or extruded bacteria of the Akkermansia muciniphila type.
After about three months, doctors summed up the experience. It turned out that both supplements significantly improved the health of volunteers, although scientists did not ask them to change their lifestyle or diet.
In particular, the level of insulin in their blood decreased by 30%, "bad" forms of cholesterol – by 8.6%. All this greatly improves the body's condition and circulation, eliminating diabetes or pre-diabetes.
Interestingly, although the mass of participants in the experiment decreased to some extent, scientists did not record changes in body mass index and in the proportion of subcutaneous fat. They do not yet know what this is related to, because they did not have the necessary equipment to accurately measure the amount of fat in different organs and limbs.
Kani concluded that the Belgian researchers confirmed that these experiments showed that dietary supplements based on Akkermansia muciniphila have a beneficial effect on health. This opens the way for their practical application.
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